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Anti-Platelet Activity of Water Dispersible Curcuminoids in Rat Platelets.

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Relation http://ir.cftri.com/11834/
http://dx.doi.org/10.1002/ptr.5274
 
Title Anti-Platelet Activity of Water Dispersible
Curcuminoids in Rat Platelets.
 
Creator Anikisetty, Maheswaraiah
Jagan Mohan Rao, L.
Akhilender Naidu, K.
 
Subject 04 Functional foods
30 Spices/Condiments
 
Description Curcuminoids are active principle of turmeric with plethora of health beneficial properties. In this study, we have
evaluated for the first time the effect of water dispersible curcuminoids on rat platelet aggregation. Curcuminoids
(10–30 μg/mL) significantly inhibited platelet aggregation induced by agonists viz., collagen, ADP and arachidonic
acid. Curcuminoids were found to be two-fold more potent than curcumin in inhibiting platelet aggregation. Intracellular
curcuminoid concentration was relatively higher than curcumin in rat platelets. Curcuminoids significantly
attenuated thromboxane A2, serotonin levels in rat platelets which play an important role in platelet aggregation.
Curcuminoid treatment increased nitric oxide (NO) levels in platelets treated with agonists. Curcuminoids inhibited
free radicals such as superoxide anion released from activated platelets, which ultimately inhibits platelet aggregation.
Further, curcuminoids inhibited 12-lipoxygenase activity and formation of 12-hydroperoxyeicosatetraenoic acid
(12-HPETE) in activated rat platelets which regulates platelet aggregation. The results suggest that curcuminoids
have remarkable anti-platelet activity by modulating multiple mechanisms involved in platelet aggregation. Thus
curcuminoids may have a therapeutic potential to prevent platelet activation related disorders
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/11834/1/Phytother%20Res%2029_2015_450-458.pdf
Anikisetty, Maheswaraiah and Jagan Mohan Rao, L. and Akhilender Naidu, K. (2015) Anti-Platelet Activity of Water Dispersible Curcuminoids in Rat Platelets. Phytotherapy Research, 29. pp. 450-458.