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Medium-chain triglycerides and monounsaturated fatty acids potentiate the beneficial effects of fish oil on selected cardiovascular risk factors in rats.

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Relation http://ir.cftri.com/12086/
http://dx.doi.org/10.1016/j.jnutbio.2015.10.005
 
Title Medium-chain triglycerides and monounsaturated fatty acids potentiate the
beneficial effects of fish oil on selected cardiovascular risk factors in rats.
 
Creator Vijay Kumar Reddy, K.
Maheshwaraiah, A.
Akhilender Naidu, K.
 
Subject 17 Fatty Acid Chemistry
Fish
 
Description Fish oil (FO) rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is known to reduce the risk of cardiovascular diseases (CVDs). Little
information is known regarding the influence of lipid composition in the background diet on the modulatory effect of FO supplementation on CVDs. The present
study was designed to investigate the influence of various background dietary lipids and FO on selected cardiovascular risk factors in rats. Adult Wistar rats were
fed semisynthetic diet with FO at 1.0% or 2.0% along with other lipids, namely, medium-chain triacylglycerols (MCTs), monounsaturated fatty acids (MUFAs), n-6
polyunsaturated fatty acids (PUFAs) and n-3 PUFAs, for 5 weeks. Some of the potent CVD risk factors were estimated in the rats. FO at 1.0% and 2.0% has
significantly reduced serum lipid peroxides, total cholesterol, triglycerides (TAGs), tumor necrosis factor-α, interleukin-6 and C-reactive protein; liver and
adipose TAG and cholesterol levels in MCT, MUFA and n-6 PUFA diet groups. Notably, these alterations were comparatively higher in 1.0% FO-substituted MCT
and MUFA diet groups. Interestingly, feeding of FO along with n-3 PUFAs did not show additive effect in attenuation of these factors. Serum liver EPA and DHA
levels were remarkably elevated in rats fed FO-enriched MCT or MUFA diets. Our results suggest that MCTs or MUFAs in the background diet might promote the
beneficial effects of FO on CVDs.
 
Date 2016
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12086/1/The%20Journal%20of%20Nutritional%20Biochemistry%2C%20Volume%2028%2C%20February%202016%2C%20Pages%2091-102.pdf
Vijay Kumar Reddy, K. and Maheshwaraiah, A. and Akhilender Naidu, K. (2016) Medium-chain triglycerides and monounsaturated fatty acids potentiate the beneficial effects of fish oil on selected cardiovascular risk factors in rats. Journal of Nutritional Biochemistry, 28. pp. 91-102. ISSN 0955-2863