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Antihyperglycemic, antihyperlipidemic and antioxidant activity of phenolic rich extract of Brassica oleraceae var gongylodes on streptozotocin induced Wistar rats

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Relation http://ir.cftri.com/12094/
http://dx.doi.org/10.1186/s40064-015-0948-0
 
Title Antihyperglycemic, antihyperlipidemic and
antioxidant activity of phenolic rich extract of
Brassica oleraceae var gongylodes on
streptozotocin induced Wistar rats
 
Creator Indumati, Sharma
Aaradhya, M.
Madhuri, Kodikonda
 
Subject 23 Vegetables
32 Antioxidants
 
Description Cruciferous vegetables, in particular those included into the Brassica genus, are good sources of a variety of nutrients
and health-promoting phytochemicals. Phenolic compounds are the major antioxidants of Brassica; hence the
contribution of Brassica vegetables to health improvement has largely been associated to their antioxidant capacity.
This study aimed to assess anti-diabetic, antilipidemic, and antioxidant activity of phenolic rich extract of Brassica
oleraceae var gongylodes (BOvG) in Wistar rats. The findings revealed that the administration of BOvG extract to diabetic
rats significantly reduced fasting blood glucose by 64% within 7 days of treatment. Additionally, BOvG extract was also
observed to normalize the diabetic rats’ lipid profile and HbA1c (Glycated hemoglobin). BOvG extract also showed
protection of liver- kidney functions, which was evidenced by the significant decrease in Blood Urea Nitrogen (BUN),
Serum glutamic oxaloacetic transaminase (SGOT) and Serum glutamic pyruvic transaminase (SGPT). The treatment also
improved the antioxidant status of the diabetic rats where the enzymatic activities of Catalase (CAT) and Super Oxide
Dismutase (SOD) were significantly increased. Furthermore, RP-HPLC analysis detected chlorogenic acid, rutin, and
sinapic acid against known standards in BOvG extract. Hence, the present investigation suggests that BOvG phenolic
rich extract (as a multi-component therapy) exhibited anti-diabetic, antilipidemic and antioxidant properties in STZinduced
diabetic rats.
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12094/1/SpringerPlus%20December%202015%2C%204%20212.pdf
Indumati, Sharma and Aaradhya, M. and Madhuri, Kodikonda (2015) Antihyperglycemic, antihyperlipidemic and antioxidant activity of phenolic rich extract of Brassica oleraceae var gongylodes on streptozotocin induced Wistar rats. SpringerPlus, 4 (212). pp. 1-7.