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Modified pectic polysaccharide from turmeric (Curcuma longa):A potent dietary component against gastric ulcer

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/12134/
http://dx.doi.org/10.1016/j.carbpol.2015.11.043
 
Title Modified pectic polysaccharide from turmeric (Curcuma longa):A potent dietary component against gastric ulcer
 
Creator Harsha, M. R
Serkad, V.
Chandra, Prakash
Shylaja, M. Dharmesh
 
Subject 01 Dietary Fiber
07 Turmeric
 
Description tNative, intact (TrPP) and modified, low-molecular-weight (MTrPP) forms of pectic polysaccharides iso-lated from turmeric were evaluated for ulcer-preventive potentials in in vitro and in vivo models. Dataindicated that MTrPP possessed significantly better ulcer-preventive property than TrPP; inhibitingulcer scores up to 85%. Results were substantiated by effective muco-protection, H+,K+-ATPase down-regulation, inhibition of H. pylori growth/adherence, higher antioxidant/cytoprotective mechanisms.Structural data indicated TrPP and MTrPP differ in their molecular weights and structural characteristicswith different sugar compositions and side chain ratios. MTrPP was rich in galacturonic acid (687 mg/g;TrPP—544 mg/g) and galactose (52.9%; TrPP—21.7%). Results were substantiated by NMR/FTIR data indi-cating the presence of homogalacturonan and rhamnogalacturonam-I containing galactans. By virtue ofbinding to inflammatory marker (galectin-3), galactans may reduce inflammation induced ulcerations.The low molecular weight of MTrPP (155 kDa; TrPP—13 kDa) may increase its bioavailability than TrPP,thus MTrPP may possess higher antiulcer potential.
 
Date 2016
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://ir.cftri.com/12134/1/Carbohydrate%20Polymers%2C%20Volume%20138%2C%2015%20March%202016%2C%20Pages%20143-155.pdf
Harsha, M. R and Serkad, V. and Chandra, Prakash and Shylaja, M. Dharmesh (2016) Modified pectic polysaccharide from turmeric (Curcuma longa):A potent dietary component against gastric ulcer. Carbohydrate Polymers, 138. pp. 143-155.