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Antioxidant and antibacterial properties of phenolic extract from Carum carvi L.

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Relation http://ir.cftri.com/12196/
http://dx.doi.org/10.1016/j.jopr.2013.03.028
 
Title Antioxidant and antibacterial properties of phenolic extract
from Carum carvi L.
 
Creator Thippeswamy, N. B.
Akhilender Naidu, K.
Rajeshwara, N. Achur
 
Subject 30 Spices/Condiments
32 Antioxidants
 
Description Background: A wide variety of phenolic substances derived from herbs and spices possess
potent antioxidant, anti-inflammatory, antimutagenic, anticarcinogenic and antibacterial
activities which contribute to their chemo preventive potential. In the present study, we
have investigated the antioxidant and antibacterial capabilities of the phenolic extract
from Carum carvi.
Methods: The phenolic compounds from defatted C. carvi powder was extracted using
water, 50% alcohol and 1:1 mixture of methanol (70%) and acetone (70%) and the yield was
found to be 8.76, 12.63 and 50.20 mg/g, respectively. The phenolic extract was assessed for
its antioxidant potential to scavenge 2,2-dipicryl-1-picrylhydrazyl (DPPH) and superoxide
anion radical, inhibition of DNA degradation, and reducing ability as well as antibacterial
activity.
Results and discussions: The phenolic extract showed 50% DPPH scavenging activity at
2.7 mg/ml as compared to 4.19 mg/ml for butylated hydroxyanisole (BHA) and 8.35 mg/ml for
butylated hydroxy toluene (BHT). The extract was also found to scavenge superoxide anion
radicals with an IC50 value of 35 mg/ml. The reducing ability of the extract was found to be
better than BHT and comparable to BHA. The C. carvi phenolic extract also offered dose
dependent protection against DNA damage. Further, C. carvi phenolic extract effectively
inhibited the growth of Gram-positive bacteria as compared to Gram-negative bacteria.
Conclusions: The total phenolic compounds present in C. carvi were found to possess very
good antioxidant and moderate antibacterial activities at microgram quantities which may
be exploited as potential natural pharmaceutical drugs.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Identifier http://ir.cftri.com/12196/1/Journal%20of%20Pharmacy%20Research%2C%20Volume%207%2C%20Issue%204%2C%20April%202013%2C%20Pages%20352-357.pdf
Thippeswamy, N. B. and Akhilender Naidu, K. and Rajeshwara, N. Achur (2013) Antioxidant and antibacterial properties of phenolic extract from Carum carvi L. Journal of Pharmacy Research, 7 (4). pp. 352-357.