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Mammalian safety of Decaleside II in the laboratory mouse

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/12197/
 
Title Mammalian safety of Decaleside II in the laboratory mouse
 
Creator Rajashekar, Y.
Shivanandappa, T.
 
Subject 10 Plants
26 Pesticide Chemistry
 
Description Decaleside II, a novel trisaccharide isolated from the edible roots of Decalepis hamiltonii,
belongs to a new class of natural insecticides. We have evaluated the mammalian safety
of Decaleside II in the laboratory mouse. Our results on acute and sub acute toxicity study
suggest that Decaleside II is not toxic to the laboratory mice as there were no symptoms
of toxicity or mortality up to 2400 mg/kg bw. Haematological profile was unaltered and
serum profiles of enzymes were not significantly affected. The lack of toxicity of Decaleside
is attributed to the 1,4 � linkage of the sugars which are easily hydrolyzed by the digestive
enzymes such as glucosidases. The selective toxicity to insects and mammalian safety of
Decaleside II makes them highly suitable for use as novel grain protectants of natural origin.
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://ir.cftri.com/12197/1/Toxicology%20Reports%2C%20Volume%201%2C%202014%2C%20Pages%20969-972.pdf
Rajashekar, Y. and Shivanandappa, T. (2014) Mammalian safety of Decaleside II in the laboratory mouse. Toxicology Reports, 1. pp. 969-972.