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A New Hypothesis for the Precursor of Aflatoxin Biosynthesis by Aspergillus flavus

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Title A New Hypothesis for the Precursor of Aflatoxin
Biosynthesis by Aspergillus flavus
 
Creator Mayura, K.
Basappa, S. C.
Sreenivasamurthy, V.
 
Subject 04 Biosynthesis
 
Description A comparative study between toxigenic and non-toxigenic, strains of A. flavus was made to elucidate the precursor
specificity in aflatoxln biosynthesis using carbohydrate and rat substrates. It was found that non-toxigenic strain- of -A.flavus produced more ethanol than the toxigenic strain and more so under tbe Influence of rice bran oil. This gave a due that aldehyde may be a precursor in aflatoxin biosynthesis rather than acetate. Arselite, an inhibitor of lipoic dehydrogenase increased alcohol accumulation but decreased aflatoxin accumulation without affecting the mycelial growth.
But when ethanol is supplemented to the arsenite system, the aflatoxin accumulation was equal to control indicating
the diversion or aldehyde to aflatoxin synthesis. This perhaps takes place by feedback inhibition of the conversion of
aldehyde to ethanol by the added ethanol. The aflatoxin biosynthesis in resting cells was not affected when alloxan,
a specific inhibitor or coenzyme A, was added. This suggests that CoA required in rat synthesis Is not perhaps
directly involved In aflatoxin biosynthesis. These data strengthen the hypothesis that it may be the aldehyde mediated by some condensing enzymes which is the bask unit for aflatoxln biosynthesis
 
Date 1985
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12234/1/Journal%20of%20Food%20Science%20and%20Technology%2C%20India%2C%20Volume-22%282%20%281985%29%20130-133.pdf
Mayura, K. and Basappa, S. C. and Sreenivasamurthy, V. (1985) A New Hypothesis for the Precursor of Aflatoxin Biosynthesis by Aspergillus flavus. Journal of Food Science and Technology, 22 (2). pp. 130-133. ISSN 0022-1155