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Hypolipidemic and antioxidant effects of dietary fenugreek (Trigonella foenum-graecum) seeds and garlic (Allium sativum) in high-fat fed rats

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Relation http://ir.cftri.com/12257/
http://dx.doi.org/10.1016/j.fbio.2016.01.002
 
Title Hypolipidemic and antioxidant effects of dietary fenugreek (Trigonella
foenum-graecum) seeds and garlic (Allium sativum) in high-fat fed rats
 
Creator Mukthamba, P.
Srinivasan, K.
 
Subject 08 Fenugreek
32 Antioxidants
 
Description Hypolipidemic and antioxidant influences of dietary fenugreek (Trigonella foenum-graecum) seeds (10%)
and garlic (Allium sativum) (2% powder), individually and in combination for 8 weeks were evaluated in
high-fat diet (HFD) fed Wistar rats. Increased serum triglycerides and LDL-cholesterol caused by HFD was
countered by these dietary interventions, while HDL-cholesterol was increased. Increase in cholesterol:
phospholipid ratio and atherogenicity index caused by HFD was lowered by dietary fenugreekþgarlic.
Dietary fenugreek or fenugreekþgarlic countered the increase in triglycerides and cholesterol: phospholipid
ratio in the heart tissue of HFD-fed rats. The increase in liver triglycerides and cholesterol as a
result of HFD was countered by dietary fenugreekþgarlic. All the 3 dietary interventions lowered dietary
fat absorption in HFD-fed situation. The elevated lipid peroxides in serum, cardiac, and liver tissue of
HFD-fed rats was countered by dietary fenugreekþgarlic. This was accompanied by increased glutathione
concentration in serum and liver and of ascorbic acid in heart and liver. Activities of antioxidant
enzymes were enhanced by dietary fenugreekþgarlic in serum and heart in HFD-fed situation. Thus,
dietary fenugreekþgarlic produced higher lipid lowering effect and improved the antioxidant status in
high-fat fed rats which suggest that these nutraceuticals may have higher cardio protective influence
when consumed together.
 
Date 2016
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12257/1/Food%20Bioscience%2014%20%282016%29%201%E2%80%939.pdf
Mukthamba, P. and Srinivasan, K. (2016) Hypolipidemic and antioxidant effects of dietary fenugreek (Trigonella foenum-graecum) seeds and garlic (Allium sativum) in high-fat fed rats. Food Bioscience, 14. pp. 1-9.