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Beneficial Effect of a Probiotic Lactobacillus Fermentum Cfr 2195 in Trinitrobenzenesulfonate Induced Colitis in Rat

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Title Beneficial Effect of a Probiotic Lactobacillus Fermentum Cfr 2195 in
Trinitrobenzenesulfonate Induced Colitis in Rat
 
Creator GirishKumar, B.
David, Elisha Henry
Krishnapura, Srinivasan
Prapulla, S. G.
 
Subject 04 Microbiology
 
Description The intestinal anti-inflammatory effects of L. fermentum CFR 2195, isolated from healthy breast fed infant’s fecal
matter was evaluated. Ulcerative colitis was induced in Wistar rats by intracolonic administration of TNBS. L.
fermentum CFR 2195 was administered orally (5x108 colony-forming units) to rats daily for 3 weeks, starting 2 weeks
prior to the induction of ulcerative colitis. Normal control group of rats were fed solely with basal diet. Probiotic
control group was fed with basal diet along with probiotic administration. Among the colitis induced rats, the TNBS
control group was fed with basal diet whereas, the TNBS-probiotic group was fed with basal diet along with probiotic
administration. Colonic damage was evaluated both biochemically, histologically and the luminal contents were used
for the microbiological studies. The intestinal anti-inflammatory effects of L. fermentum CFR 2195 were evidenced by a
significant reduction in colonic myeloperoxidase activity (P
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12276/1/Annals.%20Food%20Science%20and%20Technology_2012.pdf
GirishKumar, B. and David, Elisha Henry and Krishnapura, Srinivasan and Prapulla, S. G. (2012) Beneficial Effect of a Probiotic Lactobacillus Fermentum Cfr 2195 in Trinitrobenzenesulfonate Induced Colitis in Rat. Annals Food Science and Technology, 13 (2). pp. 231-239.