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Protective effect of dietary tender cluster beans (Cyamopsis tetragonoloba) in the gastrointestinal tract of experimental rats

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Relation http://ir.cftri.com/12282/
http://dx.doi.org/10.1139/apnm-2012-0091
 
Title Protective effect of dietary tender cluster beans (Cyamopsis tetragonoloba)
in the gastrointestinal tract of experimental rats
 
Creator Shubhra, Pande
Krishnapura, Srinivasan
 
Subject 22 Legumes-Pulses
32 Antioxidants
 
Description In this study, the gastrointestinal protective effect of soluble, dietary fiber-rich tender cluster beans, with respect to the
activities of antioxidant enzymes and the concentration of antioxidant molecules, was examined in Wistar rats. Dietary intervention
with tender cluster beans (15% freeze-dried powder in the diet for 8 weeks) significantly enhanced the activities of antioxidant enzymes
(superoxide dismutase, catalase, glutathione reductase, glutathione-S-transferase, and GPX) and the concentrations of antioxidant
molecules in both gastric and intestinal mucosa. Further, in combination with capsaicin (0.01%), the beneficial effect was even higher.
There is a strong indication that tender cluster beans offer a significant gastroprotective effect, and a much greater effect when
combined with capsaicin in terms of increased antioxidant status. In a separate study, these dietary components were found to
alleviate the diminished activities of antioxidant enzymes and antioxidant molecules in gastric and intestinal mucosa under conditions
of ethanol-induced oxidative stress. The gastroprotective effect of the cluster bean was also reflected in its positive effect on
gastric mucosal glycoproteins, resulting in a lowering of mucosal injury. Incidentally, the serum and liver also showed an elevated
antioxidant status, thus suggesting desirable lowered oxidative stress results when tender cluster beans are consumed.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12282/1/APNM%20Article%20%282013%29.pdf
Shubhra, Pande and Krishnapura, Srinivasan (2013) Protective effect of dietary tender cluster beans (Cyamopsis tetragonoloba) in the gastrointestinal tract of experimental rats. Applied Physiology Nutrition and Metabolism, 38. pp. 169-176.