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STRUCTURE PREDICTION OF AN OUTER MEMBRANE PROTEIN (PORIN) OF NEISSERIA LACTAMICA USING BIOINFORMATICS TOOLS

KrishiKosh

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Title STRUCTURE PREDICTION OF AN OUTER MEMBRANE PROTEIN (PORIN) OF NEISSERIA LACTAMICA USING BIOINFORMATICS TOOLS
 
Creator Jena, malabika
 
Contributor Pradhan, S K
 
Subject Diplococcus bacterium, β-D-galactosidase, Porins, homology modeling
 
Description Neisseria lactamica is a gram-negative diplococcus bacterium, a commensal species of the nasopharynx commonly found in young children.They are able to produce β-D-galactosidase and ferment lactose. There is an inverse relationship between colonization by N. lactamica and Neisseria meningitidis. Carriage of N. lactamica has been associated with decreased incidence of invasive meningococcal disease. Neisseria lactamica plays an important role in porin and decreases incidence of invasive meningococcal disease. Porins are beta barrel proteins that cross a cellular membrane and act as a pore through which molecules can diffuse. Unlike other membrane transport proteins, porins are large enough to allow passive diffusion, i.e., they act as channels that are specific to different types of molecules. They are present in the outer membrane of Gram-negative bacteria and some Gram-positive bacteria of the group Mycolata (mycolic acid-containing actinomycetes), the mitochondria, and the chloroplast. The bactrium Neisseria lactamica having an outer membrane protein porin (ABS44951.1) with 337 amino acids length.plays a major role in cell transport.The secondary structure of porin was predicted using bioinformatics tools of Expasy server. The three dimensional structure(homology modeling) of Porin was also predicted using Modeller 9v8 to better understand its functions.
 
Date 2017-01-07T14:54:06Z
2017-01-07T14:54:06Z
2011
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/95025
 
Language en
 
Relation Th;116