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A Short-Term Toxicity Study of Aspergillus Carbonarius Carotenoid

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/12299/
http://dx.doi.org/10.1177/1091581811430402
 
Title A Short-Term Toxicity Study of
Aspergillus Carbonarius Carotenoid
 
Creator Anbarasu, K.
Akshatha, H.S.
Muthukumar, S. P.
Umesh Kumar, S.
 
Subject 03 Fungi
17 Toxicology
 
Description In a pharmacokinetic study, high-performance liquid chromatography analysis of blood samples of Wistar female rats fed with
partially saturated canthaxanthin (PSC) of Aspergillus carbonarius showed the presence of the carotenoid in the plasma within
6 hours of feeding. In another study for safety assessment of PSC fed to rats over a period of 28 days at 0.05%, 0.10%, and 0.25%,
the rats showed no changes in food intake. There were no significant differences observed in body weight, hematological
parameters, or serum clinical enzymes compared to the control group not fed with PSC. Deposition of PSC in the eyes of the
rats was also not observed. The results showed that PSC-fed rats were not adversely affected as far as toxicological studies were
concerned.
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12299/1/International%20Journal%20of%20Toxicology%2031%282%29%20158-165.pdf
Anbarasu, K. and Akshatha, H.S. and Muthukumar, S. P. and Umesh Kumar, S. (2012) A Short-Term Toxicity Study of Aspergillus Carbonarius Carotenoid. International Journal of Toxicology, 31 (2). pp. 158-165.