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Antioxidant Potential of Fungal Metabolite Nigerloxin during Eye Lens Abnormalities in Galactose-Fed Rats

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Relation http://ir.cftri.com/12303/
http://dx.doi.org/10.3109/02713683.2013.802810
 
Title Antioxidant Potential of Fungal Metabolite Nigerloxin
during Eye Lens Abnormalities in Galactose-Fed Rats
 
Creator Suresha, B. S.
Srinivasan, K.
 
Subject 03 Fungi
32 Antioxidants
 
Description Background: The role of osmotic and oxidative stress has been strongly implicated in the pathogenesis of
cataract. Nigerloxin, a fungal metabolite, has been shown to possess aldose reductase inhibition and improved
antioxidant defense system in lens of diabetic rats. In the present study, the beneficial influence of nigerloxin
was investigated in galactose-induced cataract in experimental animals.
Methods: Cataract was induced inWistar rats by feeding 30% galactose in diet. Groups of galactose-fed rats were
orally administered with nigerloxin (25 and 100 mg/kg body weight/day) for 24 days.
Results: Lens aldose reductase activity was increased significantly in galactose-fed animals. Lens lipid peroxides
and advanced glycation end products were also significantly increased. Antioxidant molecule – reduced
glutathione, total thiols and activities of antioxidant enzymes superoxide dismutase and glutathione peroxidase
were decreased in the lens of galactose-fed animals. Oral administration of nigerloxin once a day for 24 days at
a dose of 100 mg/kg body weight, significantly decreased lens lipid peroxides and advanced glycation end
products in galactose-fed rats. Lens aldose reductase activity was reduced and lens antioxidant molecules and
antioxidant enzyme activities were elevated significantly by nigerloxin administration.
Conclusions: The results suggest that alteration in polyol pathway and antioxidant defense system were
countered by nigerloxin in the lens of galactose-fed animals, suggesting the potential of nigerloxin in
ameliorating the development of galactose-induced cataract in experimental animals.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12303/1/Current%20Eye%20Research%2C%202013%3B%2038%2810%29%201064%E2%80%931071.pdf
Suresha, B. S. and Srinivasan, K. (2013) Antioxidant Potential of Fungal Metabolite Nigerloxin during Eye Lens Abnormalities in Galactose-Fed Rats. Current Eye Research, 38 (10). pp. 1064-1071.