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Rats fed linseed oil in microemulsion forms enriches the cardiac sarcoplasmic reticulum lipids with docosahexaenoic acid and lower calcium transport

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Relation http://ir.cftri.com/12304/
http://dx.doi.org/10.1016/j.jff.2013.09.007
 
Title Rats fed linseed oil in microemulsion
forms enriches the cardiac sarcoplasmic reticulum
lipids with docosahexaenoic acid and lower calcium
transport
 
Creator Sugasini, D.
Lokesh, B. R.
 
Subject 11 Lipid Biochemistry
01 Oilseeds
 
Description The effect of feeding rats with whey protein or lipoid microemulsion of n-3 rich linseed oil
(LSO), and n-6 rich sunflower oil (SNO) compared to native or microemulsion forms of each
oil for 60 days on fatty acid composition, Ca2+Mg2+ ATPase, Ca2+ uptake and membrane fluidity
of rat cardiac sarcoplasmic reticulum (SR) were assessed. Rats consuming LSO in
lipoid microemulsion showed higher levels of ALA (18:3, n-3) conversion to DHA (22:6,
n-3) when compared to rats given LSO in native form. Compared to all other dietary treatments,
the alterations in the n-6/n-3 PUFA composition of SR of rats given LSO in lipoid
microemulsion effected the greatest changes in Ca2+Mg2+ ATPase activity and Ca2+ uptake
which effectively reduced Ca2+ transport. Therefore, the LSO in lipoid microemulsion
confers similar heart healthy fatty acid compositional and calcium transport changes
and potentially anti-arrhythmic effects similar to fish oils.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://ir.cftri.com/12304/1/J%20O%20U%20R%20NA%20L%20O%20F%20FUN%20C%20T%20I%20O%20N%20A%20L%20F%20O%20O%20D%20S%205%20%28%202%200%201%203%20%29%201%208%206%203%20%E2%80%931%208%207%202.pdf
Sugasini, D. and Lokesh, B. R. (2013) Rats fed linseed oil in microemulsion forms enriches the cardiac sarcoplasmic reticulum lipids with docosahexaenoic acid and lower calcium transport. Journal of Functional Foods. 1863 -1872.