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Glucose feeding during development aggravates the toxicity of the organophosphorus insecticide Monocrotophos in the nematode, Caenorhabditis elegans

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Relation http://ir.cftri.com/12313/
http://dx.doi.org/10.1016/j.physbeh.2014.04.022
 
Title Glucose feeding during development aggravates the toxicity of the
organophosphorus insecticide Monocrotophos in the nematode,
Caenorhabditis elegans
 
Creator Salim, Chinnu
Rajini, P. S.
 
Subject 17 Toxicology
 
Description Several studies have demonstrated that high glucose feeding induced oxidative stress and apoptosis thereby affecting
growth, fertility, aging and lifespan in Caenorhabditis elegans. Earlier studies from our laboratory had
clearly established the propensity of monocrotophos, an OPI to alter the physiological and behavioral responses
of C. elegans. The present study was aimed to investigate the effect of monocrotophos (MCP) on physiological/
behavioral and biochemical responses in C. elegans that were maintained on high glucose diet. We exposed the
worms through development to high glucose diet (2%) and then treated with sublethal concentrations of MCP
(0.5, 0.75, 1.5 mM).We measured the behavioral responses in terms of locomotion, physiological responses in
terms of egg laying, brood size, lifespan; morphological alterations; and biochemical responses including glucose
content. The worms exposed from egg stage through development to high glucose diet showed enhanced toxic
outcome of MCP in terms of physiological, behavioral and biochemical responses. Our studies showed that
C. elegans is a goodmodel to study glucose–OPI interactive neurotoxicity since all the responses could be studied
at ease in this organism and the outcome could be well extrapolated to those that one would expect in higher
animals.
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12313/1/Physiology%20%26%20Behavior%20131%20%282014%29%20142%E2%80%93148.pdf
Salim, Chinnu and Rajini, P. S. (2014) Glucose feeding during development aggravates the toxicity of the organophosphorus insecticide Monocrotophos in the nematode, Caenorhabditis elegans. Physiology and Behavior, 131. pp. 142-148.