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Renoprotective Effect of Coccinia indica Fruits and Leaves in Experimentally Induced Diabetic Rats

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Relation http://ir.cftri.com/12316/
http://dx.doi.org/10.1089/jmf.2012.2689
 
Title Renoprotective Effect of Coccinia indica Fruits and Leaves
in Experimentally Induced Diabetic Rats
 
Creator Abignan Gurukar, M. S.
Mahadevamma, S.
Nandini, Chilkunda D.
 
Subject 04 Diabetes Mellitus
24 Fruits
 
Description Diabetic nephropathy is one of the secondary complications of diabetes mellitus that is marked by changes in
extracellular matrix components leading to end-stage renal failure. Diet plays an important role in managing diabetes. In the
present study, the effect of Coccinia indica consumption on diabetes-mediated kidney damage was determined. Both control
and diabetic rats were fed with AIN-76 diet supplemented with C. indica fruits and leaves individually at 10% and 5%,
respectively, for a period of 2 months. Various parameters, such as fasting blood glucose, urine sugar, albumin excretion,
kidney index, and glomerular filtration rate, were ameliorated to various extents by the supplementation of C. indica in the
diet. Additionally, diabetic rats fed with diet supplemented with C. indica fruits or leaves showed improvement in glucose
tolerance compared to control diabetic rats. They also exhibited beneficial effects on key antioxidant enzymes of the kidney.
Furthermore, an increase in laminin and fibronectin as a result of diabetes was alleviated in C. indica-fed rats. These results
indicate that the consumption of C. indica is beneficial in partially containing diabetes-mediated deleterious effects on the
kidney.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12316/1/J%20Med%20Food%2016%20%289%29%202013%2C%20839%E2%80%93846.pdf
Abignan Gurukar, M. S. and Mahadevamma, S. and Nandini, Chilkunda D. (2013) Renoprotective Effect of Coccinia indica Fruits and Leaves in Experimentally Induced Diabetic Rats. Journal of Medicinal Food, 16 (9). pp. 839-846.