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Phenolic constituents and biological activities of leaf extracts of traditional medicinal plant Plectranthus amboinicus Benth (Lamiaceae)

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Relation http://ir.cftri.com/12346/
http://dx.doi.org/10.5667/tang.2013.0027
 
Title Phenolic constituents and biological activities of leaf extracts of traditional
medicinal plant Plectranthus amboinicus Benth (Lamiaceae)
 
Creator Sandeep Kumar, Gupta
Praveena, Bhatt
Joseph, G. S.
Negi, P. S.
Varadaraj, M. C.
 
Subject 04 Medicinal Plants
32 Antioxidants
 
Description Plectranthus amboinicus Benth (Lamiaceae) is a medicinal plant native to India, and its leaves are
widely used in several traditional medicinal preparations. The purpose of this study was to detect and
quantify phenolics present in ethyl acetate and acetone extracts of P. amboinicus leaves, and evaluate
their antioxidant, antibacterial, antimutagenic and anticancer activities. The HPLC chromatograms of
crude leaf extracts indicated the presence of phenolics like caffeic acid, coumaric acid, rutin, quercetin
and gallic acid, which were present in the range of 0.01 - 1.41 mg/g in ethyl acetate and 0.03 - 1.93 mg/g
in the acetone extract. The acetone extract showed statistically (p < 0.05) higher antioxidant activity
(IC50, 99.59 μg/ml) than ethyl acetate extract (IC50, 149.96 μg/ml). Statistically (p < 0.05) higher
antimutagenicity was shown by acetone extract (46.16%) as compare to ethyl acetate extract (12.16%) at
500 μg/plate concentration. The acetone extract showed higher antibacterial activity than ethyl acetate
extract, and both the extracts showed highest activity against B. cereus (375 and 625 μg/ml, respectively)
and lowest activity against Y. enterocolitica (1000 and 1125 μg/ml, respectively). Both the extracts also
showed inhibitory effect on cancer cell lines HCT-15 and MCF-7. These results suggest that the leaves of
P. amboinicus possess various biological activities, and validate the traditional use of the leaves of P.
amboinicus against cold, infection and ulceration.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12346/1/TJHOBI_2013_v3n4_32.1.pdf
Sandeep Kumar, Gupta and Praveena, Bhatt and Joseph, G. S. and Negi, P. S. and Varadaraj, M. C. (2013) Phenolic constituents and biological activities of leaf extracts of traditional medicinal plant Plectranthus amboinicus Benth (Lamiaceae). Tang Humanitas Medicine, 3 (4). pp. 1-6.