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Antioxidant Properties of Fungal Metabolite Nigerloxin in vitro

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Relation http://ir.cftri.com/12357/
http://dx.doi.org/0.1134/S0003683813060173
 
Title Antioxidant Properties of Fungal Metabolite Nigerloxin in vitro
 
Creator Suresha, B. S.
Srinivasan, K.
 
Subject 04 Fungi
32 Antioxidants
 
Description Abstract—We have recently reported the beneficial influence of the fungal metabolite nigerloxin, a new
aldose reductase inhibitor and a lipoxygenase inhibitor on oxidative stress in streptozotocin induced diabetic
rats. In the present study we have investigated the antioxidant potential of nigerloxin in vitro as compared to
one of the well known natural antioxidant, curcumin. The fungal metabolite nigerloxin was found to be an
effective antioxidant in different in vitro assays including the phosphomolybdenum, 2,2�diphenyl�1�picryl�
hydrazyl (DPPH•), 2,2'�azino�bis(3�ethylbenzothiazoline�6�sulphonic acid) (ABTS•+) and ferric reducing
antioxidant power (FRAP) methods. The antioxidant potency of nigerloxin may be attributed to its electron
donating nature. The ferric reducing potency of nigerloxin as demonstrated by FRAP assay method was even
found to be superior to that of the natural antioxidant curcumin.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12357/1/Applied%20Biochemistry%20and%20Microbiology%2C%202013%2C%20Vol.%2049%2C%20No.%206%2C%20pp.%20587%E2%80%93591.pdf
Suresha, B. S. and Srinivasan, K. (2013) Antioxidant Properties of Fungal Metabolite Nigerloxin in vitro. Applied Biochemistry and Microbiology, 49 (6). pp. 587-591.