Record Details

Acute and Subacute Toxicity Assessment of Lutein in Lutein-Deficient Mice

IR@CSIR-CFTRI

View Archive Info
 
 
Field Value
 
Relation http://ir.cftri.com/12365/
http://dx.doi.org10.1111/1750-3841.12256
 
Title Acute and Subacute Toxicity Assessment
of Lutein in Lutein-Deficient Mice
 
Creator Nidhi, Bhatiwada
Baskaran, V.
 
Subject 14 Carotenoid Chemistry
17 Toxicology
 
Description Dietary lutein consumption is lower than the actual recommended allowances to prevent macular degeneration;
thus dietary lutein supplements have been recommended. This study aimed to investigate potential adverse effect of lutein
from Tagetes erecta in lutein-deficient (LD) male mice. Preliminary acute toxicity study revealed that the LD50 exceeded
the highest dose of 10000 mg/kg BW. In a subacute study, male mice were gavaged with 0, 100, 1000 mg/kg BW/day
for a period of 4 wk. Plasma lutein levels increased dose dependently (P < 0.01) after acute and subacute feeding of lutein
in LD mice. Compared to the control (peanut oil without lutein) group, no treatment-related toxicologically significant
effects of lutein were prominent in clinical observation, ophthalmic examinations, body, and organ weights. Further,
no toxicologically significant findings were eminent in hematological, histopathological, and other clinical chemistry
parameters. In the oral subacute toxicity study, the no-observed-adverse-effect level (NOAEL) for lutein in LD mice was
determined as 1000 mg/kg/day, the highest dose tested.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://ir.cftri.com/12365/1/Journal%20of%20Food%20Science%20Vol.%2078%20Nr.%2010%202013.pdf
Nidhi, Bhatiwada and Baskaran, V. (2013) Acute and Subacute Toxicity Assessment of Lutein in Lutein-Deficient Mice. Journal of Food Science, 78 (10). pp. 1636-1642.