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Neuroprotective efficacy of a combination of fish oil and ferulic acid against 3-nitropropionic acid-induced oxidative stress and neurotoxicity in rats: behavioural and biochemical evidence

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Relation http://ir.cftri.com/12368/
http://dx.doi.org/10.1139/apnm-2013-0262
 
Title Neuroprotective efficacy of a combination of fish oil and
ferulic acid against 3-nitropropionic acid-induced oxidative
stress and neurotoxicity in rats: behavioural and biochemical
evidence
 
Creator Denny Joseph, K.M.
Dr., Muralidhara
 
Subject 19 Lipids-oils/fats
Fish
 
Description FO supplementation at higher doses for longer duration is likely to cause oxidative stress in vivo. To overcome this,
attempts have been made to enrich FO with known antioxidants/phytochemicals. In the present study, we examined the
hypothesis that a combination of FO with ferulic acid (FA), a naturally occurring phenolic compound, is likely to provide higher
degree of neuroprotection. This was examined by employing 3-nitropropionic acid (NPA), a well-known neurotoxin used to
mimic behavioural and neurochemical features of Huntington’s disease. Growing male rats administered with NPA (25 mg/kg of
body weight (bw) for 4 days) were provided with either FO (2 mL/kg bw), FA (50 mg/kg bw) or FO+FA for 2 weeks. Interestingly,
FO+FA not only offered significant protection against NPA-induced behavioural impairments, but also markedly attenuated
oxidative stress in brain regions (striatum/cerebellum) as evidenced by the reduction in reactive species, malondialdehyde,
hydroperoxides and nitric oxide (NO) levels. Further, FO+FA combination restored the activities of various antioxidant enzymes
and the levels of cytosolic calcium. In striatum, activity levels of acetylcholinesterase enzyme and dopamine levels were
markedly restored among FO+FA rats. Interestingly, NPA-induced mitochondrial dysfunctions were also attenuated among
FO+FA rats. Collectively, our findings suggest the advantage of co-treatment of FO with known antioxidants to achieve a higher
therapeutic benefit in the treatment of oxidative stress-mediated neurodegenerative conditions.
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Identifier http://ir.cftri.com/12368/1/Appl.%20Physiol.%20Nutr.%20Metab.%2039%20487%E2%80%93496%20%282014%29.pdf
Denny Joseph, K.M. and Dr., Muralidhara (2014) Neuroprotective efficacy of a combination of fish oil and ferulic acid against 3-nitropropionic acid-induced oxidative stress and neurotoxicity in rats: behavioural and biochemical evidence. Applied Physiology Nutrition and Metabolism, 39. pp. 487-496. ISSN :