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µ-Oxamido binuclear copper (II) complexes: Synthesis, crystal structure, DNA interaction and antibacterial studies

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Relation http://ir.cftri.com/12370/
http://dx.doi.org/10.1016/j.poly.2013.10.025
 
Title µ-Oxamido binuclear copper (II) complexes: Synthesis, crystal structure,
DNA interaction and antibacterial studies
 
Creator Chetana, P. R.
Ramakrishna, Rao
Debojyoti, Lahiri
Policegoudra, R. S.
Ravish, Sankolli
Aradhya, S. M.
 
Subject 24 Organic Chemistry
 
Description Four binuclear copper (II) complexes [Cu(oxpn)Cu(B)]2+ (2–5) bridged by N, N0-bis[3-(methylamino)
propyl] oxamide (oxpn), where, B is N, N-donor heterocyclic bases (viz. 2,20-bipyridine (bpy, 2), 1,10-
phenathroline (phen, 3), dipyrido[3,2-d:20,30-f]quinoxaline (dpq, 4) and dipyrido[3,2-a:20,30-c]phenazine
(dppz, 5) are synthesized, characterized by different spectroscopic and single crystal X-ray data
technique. The phen (3) and dpq (4) complexes were structurally characterized by X-ray data analysis.
Their DNA binding, oxidative cleavage and antibactirial activities were studied. The dpq (4) and dppz
(5) complexes are avid binders to the Calf thymus DNA (CT-DNA). The phen (3), dpq (4) and dppz (5)
complexes show efficient oxidative cleavage of supercoiled DNA (SC DNA) through hydroxyl radical
(�OH) pathway in the presence of Mercaptopropionic acid (MPA).
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12370/1/Polyhedron%2068%20%282014%29%20172%E2%80%93179.pdf
Chetana, P. R. and Ramakrishna, Rao and Debojyoti, Lahiri and Policegoudra, R. S. and Ravish, Sankolli and Aradhya, S. M. (2014) µ-Oxamido binuclear copper (II) complexes: Synthesis, crystal structure, DNA interaction and antibacterial studies. Polyhedron, 68. pp. 172-179.