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Optimization of Supercritical Carbon Dioxide Extraction of Phenolic Compounds from Mango Ginger Rhizome (Curcuma Amada Roxb.) Using Response Surface Methodology

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/12401/
 
Title Optimization of Supercritical Carbon Dioxide Extraction
of Phenolic Compounds from Mango Ginger Rhizome
(Curcuma Amada Roxb.) Using Response Surface
Methodology
 
Creator Krishna Murthy, T. P.
Manohar, B.
 
Subject 30 Spices/Condiments
 
Description Relying on modern methods of separation, strict quality control, advanced technology and optimal
manufacturing process, supercritical carbon dioxide (SC-CO2) is considered to offer an opportunity to efficiently and
economically improve recovery and reproducibility of natural product in its pure form. Three-level Box–Behnken
factorial design (BBD) from response surface methodology (RSM) was applied to optimize the main extraction
conditions including pressure, temperature and extraction time. The three different levels of Pressure, temperature
and time are between 100-250 bar, 40-60°C and 5-15 hrs respectively. The optimum conditions were found to be
350 bar, 60°C and 15 hrs. Under the optimum conditions, total phenolic content obtained was 152 mg GAE/total
extract, which well agreed with the predicted yield. HPLC analysis was carried out for the optimum conditions for
the identification and quantification of the phenolic compounds.
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12401/1/Biomedicine%20and%20Biotechnology%2C%202014%2C%20Vol.%202%2C%20No.%201%2C%2014-19.pdf
Krishna Murthy, T. P. and Manohar, B. (2014) Optimization of Supercritical Carbon Dioxide Extraction of Phenolic Compounds from Mango Ginger Rhizome (Curcuma Amada Roxb.) Using Response Surface Methodology. Biomedicine and Biotechnology, 2 (1). pp. 14-19.