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Microwave Assisted Synthesis And Biological Evaluation Of Potential Quinoline-2-Carboxylates Of Aromatic Compounds

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Title Microwave Assisted Synthesis And Biological Evaluation Of Potential Quinoline-2-Carboxylates Of Aromatic Compounds
 
Creator Fazal, E.
Pushpa, S. Murthy
Naidu, K. A.
Maheshwaraiah, A.
Nagarajan, S.
Sudha, B. S.
 
Subject 12 Aromatic Chemistry
 
Description Quinoline, a heterocyclic scaffold which is well known for wide spectrum of biological activities.Quinoline-2-carboxylates with aromatic compounds and a terpene is synthesized under microwave which increased the yield and shortens the reaction time comparing to conventional method reported by us. The synthesized compounds are characterized by UV-vis, IR, NMR and mass spectra and other physico-chemical methods.The compounds were evaluated for their in-vitro antioxidant, antimicrobial and antiplatelet activities. The compound 3k(2-methoxyphenyl quinoline-2-carboxylate)and 3c (p-tolyl quinoline-2-carboxylate showed potential antioxidant activity evaluated by DDPH radical scavenging activity. Anti-oxidant activity of 3k is confirmed by liver microsomal lipid peroxidation inhibition.3a(2-isopropyl-4-methylcyclohexyl quinoline-2-carboxylate), 3f (4-chlorophenyl quinoline-2-carboxylate) and 3g (4-chloro-3-methylphenyl quinoline-2-carboxylate) showed significant anti-inflammatory activity. In anti-microbial studies the compounds 3i (3,4-dimethylphenyl quinoline-2-carboxylate) and 3j (3,5-dimethylphenyl quinoline-2-carboxylate) inhibited antimicrobial growth significantly where as3a and 3h(2,5-dimethylphenyl quinoline-2-carboxylate) inhibited moderately. Inhibition of fungal growth was effective by3c, 3a(phenyl quinoline-2-carboxylate), 3c, 3d (o-tolyl quinoline-2-carboxylate), 3e(m-tolyl quinoline-2-carboxylate) and 3f.3k is a potential anti-platelet agent where as 3c is a moderate one.
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/12405/1/Indo%20American%20Journal%20of%20Pharm%20Research.20155%2802%29..pdf
Fazal, E. and Pushpa, S. Murthy and Naidu, K. A. and Maheshwaraiah, A. and Nagarajan, S. and Sudha, B. S. (2015) Microwave Assisted Synthesis And Biological Evaluation Of Potential Quinoline-2-Carboxylates Of Aromatic Compounds. Indo American Journal of Pharmaceutical Research, 5 (2). pp. 625-634.