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Synthesis, antibacterial and antimutagenic activity of zerumbonebicarbonyl analogues

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/12599/
http://dx.doi.org/10.1016/j.foodchem.2016.11.136
 
Title Synthesis, antibacterial and antimutagenic activity of zerumbonebicarbonyl
analogues
 
Creator Santosh Kumar, S. C.
Negi, P. S.
Manjunatha, J. R.
Bettadaiah, B. K.
 
Subject 30 Spices/Condiments
 
Description Synthesis of new zerumbone-bicarbonyl analogues by SeO2 oxidation is reported. Selective oxidation of
methyl at C-13 to an aldehyde and a ketone with exo-cyclic double bond between C-13 and C-6 in zerumbone
has been recognized. Both these compounds have an additional conjugated-carbonyl-functionality.
They exhibited significantly higher antimutagenic activity than zerumbone against Salmonella tester
strains. They are more active against Gram positive bacteria than Gram negative bacteria; however
zerumbone showed highest activity against E. coli, whereas its derivatives were least effective against
E. coli.
 
Date 2017
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://ir.cftri.com/12599/1/Food%20Chemistry%20221%20%282017%29%20576%E2%80%93581.pdf
Santosh Kumar, S. C. and Negi, P. S. and Manjunatha, J. R. and Bettadaiah, B. K. (2017) Synthesis, antibacterial and antimutagenic activity of zerumbonebicarbonyl analogues. Food Chemistry, 221. pp. 576-581.