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New bioactive hydrogenated linderazulene-derivatives from the gorgonian Echinogorgia complexa

DRS at CSIR-National Institute of Oceanography

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Title New bioactive hydrogenated linderazulene-derivatives from the gorgonian Echinogorgia complexa
 
Creator Manzo, E.
Ciavatta, M.L.
Gresa, M.P.L.
Gavagnin, M.
Villani, G.
Naik, C.G.
Cimino, G.
 
Subject South Indian coasts
gorgonian
linderazulene
furanosesquiterpenes
echinofuran
Echinogorgia complexa
 
Description Chemical analysis of the secondary metabolite pattern of the gorgonian Echinogorgia complexa, collected along South Indian coasts, showed the presence of two new tricyclic guaiane furanosesquiterpenes, iso-echinofuran (3) and 8,9-dihydro-linderazulene (4), co-occurring with the known echinofuran (5) and structurally related to the pigment linderazulene (1). The unprecedented molecules 3 and 4 were characterized by spectral methods, mainly by NMR techniques. Compounds 3-5 displayed moderate activity in the mitochondrial respiratory chain inhibition assay.
 
Date 2007-04-17T06:32:49Z
2007-04-17T06:32:49Z
2007
 
Type Journal Article
 
Identifier Tetrahedron Letters, vol.48(14), 2569-2571pp.
http://drs.nio.org/drs/handle/2264/595
 
Language en
 
Rights An edited version of this paper was published by Elsevier. Copyright [2007] Elsevier
 
Format 85240 bytes
application/pdf
 
Publisher Elsevier