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New bromotyrosine alkaloids from the marine sponge Psammaplysilla purpurea

DRS at CSIR-National Institute of Oceanography

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Title New bromotyrosine alkaloids from the marine sponge Psammaplysilla purpurea
 
Creator Tilvi, S.
Rodrigues, C.
Naik, C.G.
Parameswaran, P.S.
Wahidullah, S.
 
Subject marine invertebrats
bioactive compounds
alkaloids
chemical extraction
Psammaplysilla purpurea
 
Description Seven new bromotyrosine alkaloids Purpurealidin A, B, C, D, F, G, H and the known compounds Purealidin Q, Purpurealidin E, 16-Debromoaplysamine-4 and Purpuramine I have been isolated from the marine sponge Psammaplysilla purpurea. Their structure was elucidated on the basis of detailed 1D, 2D NMR and MS spectroscopic data. Purpurealidin B, 16-Debromoaplysamine-4 and Purpuramine I exhibited in vitro antimicrobial activities against E. coli, S. aureus, and V. cholerae. In addition, Purpurealidin B and 16-Debromoaplysamine-4 were also active against Shigella flexineri and Salmonella typhi while Purealidin Q was bactericidal only against Salmonella typhi.
 
Date 2008-07-02T04:52:34Z
2008-07-02T04:52:34Z
2004
 
Type Journal Article
 
Identifier Tetrahedron, Vol.60; 10207-10215p.
http://drs.nio.org/drs/handle/2264/1128
 
Language en
 
Rights Copyright [2004]. It is tried to respect the rights of the copyright holders to the best of the knowledge. If it is brought to our notice that the rights are violated then the item would be withdrawn.
 
Publisher Elsevier