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Antibacterial activity of the sponge Suberites domuncula and its primmorphs: Potential basis for epibacterial chemical defense

DRS at CSIR-National Institute of Oceanography

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Title Antibacterial activity of the sponge Suberites domuncula and its primmorphs: Potential basis for epibacterial chemical defense
 
Creator Thakur, N.L.
Hentschel, U.
Krasko, A.
Pabel, C.T.
Anil, A.C.
Mueller, W.E.G.
 
Subject marine invertebrates
antibiotics
defence mechanisms
protective behaviour
bacterial diseases
proteins
cloning
metabolites
Suberites domuncula
 
Description The epibacterial chemical defense of the marine sponge Suberites domuncula was explored by screening sponge extract, sponge primmorph (3-D aggregates containing proliferating cells) extract and sponge-associated as well as primmorph-associated bacteria for antibacterial activity. 16S rDNA sequencing revealed that the antimicrobially active bacteria belonged to the alpha- and gamma-subdivisions of Proteobacteria (alpha-Proteobacterium MBIC 3368, Idiomarina sp. and Pseudomonas sp., respectively). Moreover, a recombinant perforin-like protein was cloned from S. domuncula that displayed strong antibacterial activity. Based on these observations, it is proposed that the sponge may be provided with a direct (by producing antibacterial metabolites) as well as an indirect (with the help of associated bacteria) epibacterial defense.
 
Date 2008-07-18T05:07:18Z
2008-07-18T05:07:18Z
2003
 
Type Journal Article
 
Identifier Aquatic Microbial Ecology, Vol.31; 77-83p.
http://drs.nio.org/drs/handle/2264/1203
 
Language en
 
Rights Copyright [2003]. It is tried to respect the rights of the copyright holders to the best of the knowledge. If it is brought to our notice that the rights are violated then the item would be withdrawn.
 
Publisher Inter Research