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Nitrite-induced enhancement of toxicity of phenanthrene in fish and its implications for coastal waters

DRS at CSIR-National Institute of Oceanography

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Title Nitrite-induced enhancement of toxicity of phenanthrene in fish and its implications for coastal waters
 
Creator Shailaja, M.S.
Rodrigues, A.
 
Subject marine fish
toxicity
marine pollution
pollution effects
aromatic hydrocarbons
liver
damage
denitrification
anthropogenic factors
Oreochromis massambicus
 
Description Coastal areas are prone to varying degrees of anthropogenic chemical contamination. In many coastal environments experiencing reducing conditions in the water column, nitrite is produced as a result of denitrification. With a view to determining the effect of a natural stress such as the presence of nitrite in water on the xenobiotic metabolism in fish, the euryhaline cichlid Oreochromis mossambicus was exposed for up to 9 days to environmentally relevant concentrations of water-borne nitrite and phenanthrene, a polycyclic aromatic hydrocarbon. Analyses of different biomarkers in the treated fish indicated significant increase in the metabolism of phenanthrene as a result of exposure to nitrite. For example, the activity of the biotransformation enzyme measured, as 7-ethoxyresorufin-O-deethlase activity was, in the presence of 1 mu M nitrite, nearly twice that produced by phenanthrene alone. Similarly, biliary fixed fluorescence values reflecting phenanthrene and its metabolites were rendered 1.7 times higher when exposed simultaneously to nitrite. Contact with nitrite and phenanthrene together also led to severe hepatic damage with possible cell death as inferred from the large enhancement in sorbitol dehydrogenase activity in the serum and reduced liver somatic index
 
Date 2008-07-18T05:08:36Z
2008-07-18T05:08:36Z
2003
 
Type Journal Article
 
Identifier Estuarine, Coastal and Shelf Science, Vol.56; 1107-1110p.
http://drs.nio.org/drs/handle/2264/1222
 
Language en
 
Rights Copyright [2003]. It is tried to respect the rights of the copyright holders to the best of the knowledge. If it is brought to our notice that the rights are violated then the item would be withdrawn.
 
Publisher Elsevier