ICAR Research Data Repository for Knowledge Management
A serine protease inhibitor from hemolymph of green mussel, Perna viridis
DRS at CSIR-National Institute of Oceanography
View Archive Info| Field | Value | |
| Title |
A serine protease inhibitor from hemolymph of green mussel, Perna viridis
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| Creator |
Khan, M.S.
Goswami, U. Rojatkar, S.R. Khan, M.I. |
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| Description |
Bioactivity guided fractions of cell-free hemolymph of bacterially challenged marine mussel, Perna viridis led to the isolation of a novel quaternary alkaloid 1, which was identified by its spectral data. The isolated molecule 1 has been found to be a potent serine protease inhibitor (SPI) showing IC sub(50) and K sub(i) values of 102.5 and 97.1-104.68 mu M, respectively. The E sub(t)/K sub(i) value of SPI is 6.3, whereas E sub(t)/K sub(m) value is 1.04. The Van't Hoff analysis showed that the value of K sub(i) decreases with increase in temperature, and the binding of the inhibitor is entropically driven.
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| Date |
2008-07-22T06:51:37Z
2008-07-22T06:51:37Z 2008 |
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| Type |
Journal Article
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| Identifier |
Bioorganic and Medicinal Chemistry Letters, Vol.18; 3963-3967p.
http://drs.nio.org/drs/handle/2264/1302 |
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| Language |
en
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| Rights |
Copyright [2008]. It is tried to respect the rights of the copyright holders to the best of the knowledge. If it is brought to our notice that the rights are violated then the item would be withdrawn.
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| Publisher |
Elsevier
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