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Two selective novel triterpene glycosides from sea cucumber, Telenata ananas: Inhibitors of chemokine receptor-5

DRS at CSIR-National Institute of Oceanography

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Title Two selective novel triterpene glycosides from sea cucumber, Telenata ananas: Inhibitors of chemokine receptor-5
 
Creator Hegde, V.R.
Chan, T.-M.
Pu, H.
Gullo, V.P.
Patel, M.G.
Das, P.
Wagner, N.
Parameswaran, P.S.
Naik, C.G.
 
Subject chemical extraction
glycosides
bioactive compounds
chemoreception
inhibitors
Telenata ananas
 
Description The aqueous methanolic extract of a sea cucumber was found to contain two triterpene glycosides 1 and 2. The structures of 1 and 2 were established based on high-resolution NMR studies. Compounds 1 and 2 exhibited inhibitory activity (K sub(i)) of 30 and 5 mu M, respectively, in a chemokine receptor subtype 5 (CCR5) assay. Both compounds did not show any significant inhibition in a CXCR2 assay at 50 mu M, suggesting their selectivity for the CCR5 receptor
 
Date 2008-08-03T10:23:23Z
2008-08-03T10:23:23Z
2002
 
Type Journal Article
 
Identifier Bioorganic Medicinal Chemistry Letters,: Vol. 12; 3203-3205p.
http://drs.nio.org/drs/handle/2264/1344
 
Language en
 
Rights Elsevier Science Ltd
 
Publisher Pergamon