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T-antigen binding lectin with antibacterial activity from marine invertebrate, sea cucumber (Holothuria scabra): Possible involvement in differential recognition of bacteria

DRS at CSIR-National Institute of Oceanography

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Title T-antigen binding lectin with antibacterial activity from marine invertebrate, sea cucumber (Holothuria scabra): Possible involvement in differential recognition of bacteria
 
Creator Gowda, N.M.
Goswami, U.
Khan, M.I.
 
Subject marine invertebrates
coelomic fluids
Holothuria scabra
antibiotics
 
Description In invertebrates, cellular and humoral components are evolved to maintain their body immunity and integrity. Both these factors respond to different antigens such as microorganisms, vertebrate erythrocytes and foreign proteins. In this article, we report a study of a lectin (HSL) involved in immune response in the echinoderm, sea cucumber (Holothuria scabra). Correlative studies indicate that the expression of this defensive lectin is induced by bacterial challenge, wherein cell wall glycoconjugates of bacteria are involved in lectin induction. HSL showed strong broad spectrum antibacterial activity against both grampositive and gram-negative bacteria. Under in vitro conditions, purified HSL mediate agglutination of the test bacteria, there by indicating a possible mode of action in physiological situation.
 
Date 2008-11-25T09:26:08Z
2008-11-25T09:26:08Z
2008
 
Type Journal Article
 
Identifier Journal of Invertebrate Pathology, vol.99; 141-145p.
http://drs.nio.org/drs/handle/2264/1499
 
Language en
 
Rights Copyright [2008]. All efforts have been made to respect the copyright to the best of our knowledge. Inadvertent omissions, if brought to our notice, stand for correction and withdrawal of document from this repository.
 
Publisher Elsevier