Record Details

Antispasmodic action of 5-methyl benzoxazoline-2-one: A preliminary study

DRS at CSIR-National Institute of Oceanography

View Archive Info
 
 
Field Value
 
Title Antispasmodic action of 5-methyl benzoxazoline-2-one: A preliminary study
 
Creator DeSouza, R.D.
Bhandare, P.N.
Fernandes, N.
Wahidullah, S.
DeSouza, L.
 
Subject bioactiv compounds
drugs
screening
 
Description In the present study, compound (1) depressed both phases of the dose-response curve. The marked effect on 5-HT response cannot be attributed solely to an antimuscarinic action of the compound which was much less (66%) as compared to (88%) in the case of 5-HT. The varying inhibitory effect of the compound of different spasmogens acting via diverse mechanisms suggests that its locus of action may be at a post receptor site, at some step in the transduction pathway. Further work is needed to elucidate the exact mode of action of this compound
 
Date 2009-01-12T08:56:38Z
2009-01-12T08:56:38Z
1997
 
Type Journal Article
 
Identifier Indian Journal of Pharmacology, Vol.29; 327-328p.
http://drs.nio.org/drs/handle/2264/2013
 
Language en
 
Rights Copyright [1997]. All efforts have been made to respect the copyright to the best of our knowledge. Inadvertent omissions, if brought to our notice, stand for correction and withdrawal of document from this repository.
 
Publisher Indian Pharmacological Society