Record Details

Antifouling activity exhibited by secondary metabolites of the marine sponge, Haliclona exigua (Kirkpatrick)

DRS at CSIR-National Institute of Oceanography

View Archive Info
 
 
Field Value
 
Title Antifouling activity exhibited by secondary metabolites of the marine sponge, Haliclona exigua (Kirkpatrick)
 
Creator LimnaMol, V.P.
Raveendran, T.V.
Parameswaran, P.S.
 
Subject antifouling substances
chemical extraction
Haliclona exigua
marine invertebrates
 
Description Bioassay guided purification of the acetone extract of the marine sponge, Haliclona exigua, (Gulf of Mannar, India) yielded a fraction rich in bis-1-oxaquinolizidine alkaloids, active against seven strains of fouling bacteria as well as cyprids of the cosmopolitan barnacle, Balanus amphitrite. The major alkaloids in the mixture have been tentatively identified as nor-araguspongine C (33.76%), araguspongine C (6.49%), dihydroxy araguspongine (36.36%), methyl and dimethyl derivatives of the latter (12.98 and 10.38%, respectively) from HRMS studies. The lower EC sub(50) (6.6 mew g/ml as against the US Navy standard of 25 mg/ml for NPAs) and low toxicity (LC sub(50) 18 mew g/ml as compared to 0.00001 mew g/ml for TBT) values, coupled with its favourable therapeutic ratio (2.7 as against the requirement of >1) makes these compounds ideal NPAs in environmentally compatible antifouling coatings
 
Date 2009-03-30T07:41:25Z
2009-03-30T07:41:25Z
2009
 
Type Journal Article
 
Identifier International Biodeterioration & Biodegradation, vol.63(1); 67-72
http://drs.nio.org/drs/handle/2264/2597
 
Language en
 
Rights An edited version of this paper was published by Elsevier. Copyright [2009] Elsevier
 
Publisher Elsevier