Record Details

Aspernolides A and B, butenolides from a marine-derived fungus Aspergillus terreus

DRS at CSIR-National Institute of Oceanography

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Title Aspernolides A and B, butenolides from a marine-derived fungus Aspergillus terreus
 
Creator Parvatkar, R.R.
DeSouza, C.
Tripathi, A.
Naik, C.G.
 
Subject Aspergillus terreus
Marine natural products
Butenolides
Aspernolides
Chemical extraction
Bioactive compounds
 
Description Two aromatic butenolides, aspernolides A and B along with the known metabolites, butyrolactone I, terrein and physcion were isolated from the fermentation broth of a soft coral derived fungus Aspergillus terreus. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute stereochemistry of aspernolides A (1) and B (2) was established by their preparation from the known butyrolactone I. Biogenetically aspernolides A and B must be derived from butyrolactone I, a well known specific inhibitor of cyclin dependent kinase (cdk) from A. terreus. When tested, aspernolide A exhibited mild cytotoxicity against cancer cell lines
 
Date 2009-03-31T10:48:13Z
2009-03-31T10:48:13Z
2009
 
Type Journal Article
 
Identifier Phytochemistry, vol.70(1); 128-132
http://drs.nio.org/drs/handle/2264/2611
 
Language en
 
Rights An edited version of this paper was published by Elsevier. Copyright [2009] Elsevier
 
Publisher Elsevier