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Antibacterial Activity of 2- (2',4'- Dibromophenoxy) -4, 6 - dibromophenol from Dysidea granulose

DRS at CSIR-National Institute of Oceanography

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Title Antibacterial Activity of 2- (2',4'- Dibromophenoxy) -4, 6 - dibromophenol from Dysidea granulose
 
Creator DivyaShridhar, M.P.
Mahajan, G.B.
Kamat, V.P.
Naik, C.G.
Parab, R.R.
Thakur, N.R.
Mishra, P.D.
 
Subject marine sponge
Antibacterial Activity
Indian Ocean
Dysidea granulosa
 
Description 2 - (2',4'- Dibromophenoxy) - 4, 6 - dibromophenol isolated from the marine sponge Dysidea granulosa (Bergquist) collected off the coast of Lakshadweep islands, Indian Ocean, exhibited potent and broad spectrum in-vitro antibacterial activity, especially against methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), vancomycin resistant Enterococci (VRE), vancomycin sensitive Enterococci (VSE) and Bacillus spp. Minimal inhibitory concentration (MIC) was evaluated against 57 clinical and standard strains of Gram positive and Gram negative bacteria. The observed MIC range was 0.117-2.5 mu g / mL against all the Gram positive bacteria and 0.5 - 2 mu g / mL against Gram negative bacteria. The in-vitro antibacterial activity observed was better than that of the standard antibiotic linezolid, a marketed anti-MRSA drug. The results establish 2 - (2?,4?-dibromophenoxy) - 4, 6 - dibromophenol, as a potential lead molecule for anti-MRSA and anti-VRE drug development.
 
Date 2009-10-06T09:47:03Z
2009-10-06T09:47:03Z
2009
 
Type Journal Article
 
Identifier Marine Drugs, vol. 7(3); 464-471
http://drs.nio.org/drs/handle/2264/3406
 
Language en
 
Rights ? 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
This article is an open-access article distributed under the terms and conditions of the Creative
Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
 
Publisher Molecular Diversity Preservation International