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Natural product antifoulants from the octocorals of Indian waters

DRS at CSIR-National Institute of Oceanography

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Title Natural product antifoulants from the octocorals of Indian waters
 
Creator Raveendran, T.V.
LimnaMol, V.P.
Parameswaran, P.S.
 
Subject Natural Product Antifoulants
Cladiella krempfi
Sinularia kavarattiensis
Subergorgia reticulata
 
Description Natural Product Antifoulants (NPAs) have been proposed as one of the best alternatives for the globally banned toxic biocide -TBT-in antifouling coatings. In search of NPAs from Indian waters twenty nine species of Octocorals, collected from Gulf of Mannar and Lakshadweep islands, were screened for their antifouling potential against the cyprids of the cosmopolitan biofouler, Balanus amphitrite. The crude extracts of 8 species of these corals (Cladiella krempfi, Lobophytum irregulare, Lobophytum sarcophytoides, Sarcophyton ehrenbergi, Sarcophyton glaucum, Sinularia kavarattiensis, Melitodes sp. and Subergorgia reticulata) exhibited relatively high settlement inhibition properties. The bioassay-guided purification of the crude extracts of 3 active and abundant specieseCladiella krempfi, Sinularia kavarattiensis and Subergorgia reticulataeyielded five NPAs, (l?E,50E) -2-(20,60-dimethylocta-l?,50,70-trienyl)-4-furoic acid 1, (-)-6-a-hydroxy polyanthellin A 2, (+)-(7R,10S)-2-methoxy calamenene 3, (+)-(7R,10S)-2,5-dimethoxy calamenene 4 and (+)-(7R,10S)-2-methoxy,5-acetoxy calamenene 5). Among these, 5 exhibited high future prospects on account of its low EC sub(50) value (0.0335 mu g/ml) and high therapeutic ratio (799)
 
Date 2011-01-04T07:01:16Z
2011-01-04T07:01:16Z
2011
 
Type Journal Article
 
Identifier International Biodeterioration & Biodegradation, vol.65(1); 2011; 265-268
no
http://drs.nio.org/drs/handle/2264/3769
 
Language en
 
Relation Int_Biodeterior_Biodegrad_65_265.jpg
 
Rights An edited version of this paper was published by Elsevier. Copyright [2011] Elsevier
 
Publisher Elsevier