Record Details

Statins: 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors demonstrate anti-atherosclerotic character due to their antioxidant capacity

DRS at CSIR-National Institute of Oceanography

View Archive Info
 
 
Field Value
 
Title Statins: 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors demonstrate anti-atherosclerotic character due to their antioxidant capacity
 
Creator Puttananjaiah, M.H.
Dhale, M.A.
Gaonkar, V.
Keni, S.
 
Subject Antioxidant
Lipid peroxidation
Hydroxyl radical
Atherosclerosis
 
Description Atherosclerosis is a chronic inflammatory disease of multiple etiologies. It is associated with the accumulation of oxidized lipids in arterial lesions leading to coronary heart disease. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (commonly known as statins) are widely used in cardiovascular disease prevention to lower the cholesterol. The antioxidant activity of HMG-CoA reductase inhibitors was studied by lipid peroxidation inhibition assay, DPPH, and hydroxyl radical scavenging-activity methods. The lovastatin (93%) and simvastatin (96%) showed significant action of lipid peroxidation inhibition compared to other HMG-CoA reductase inhibitors. The DPPH radical and hydroxyl radical scavenging activity of simvastatin was 38% and 33%, respectively. The oxidative modification of serum lipid due to reactive oxygen species causes atherosclerosis. This study revealed the importance of lovastatin and simvastatin to prevent oxidative stress-related cardiovascular diseases
 
Date 2011-03-09T10:56:07Z
2011-03-09T10:56:07Z
2011
 
Type Journal Article
 
Identifier Applied Biochemistry and Biotechnology, vol.163(2); 2011; 215-222
http://drs.nio.org/drs/handle/2264/3812
 
Language en
 
Rights An edited version of this paper was published by Springer. This paper is for R & D purpose and Copyright [2011] Springer.
 
Publisher Springer