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Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids

DRS at CSIR-National Institute of Oceanography

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Title Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids
 
Creator Al-Mourabit, A.
Zancanella, M.A.
Tilvi, S.
Romo, D.
 
Subject marine alkaloids
asymmetric syntheses
structural complexity
 
Description The pyrrole-2-aminoimidazole (P-2-AI) alkaloids are a growing family of marine alkaloids, now numbering well over 150 members, with high topographical and biological information content. Their intriguing structural complexity, rich and compact stereochemical content, high N to C ratio (~1 : 2), and increasingly studied biological activities are attracting a growing number of researchers from numerous disciplines world-wide. This review surveys advances in this area with a focus on the structural diversity, biosynthetic hypotheses with increasing, but still rare, verifying experimental studies, asymmetric syntheses, and biological studies, including cellular target receptor isolation studies, of this stimulating and exciting alkaloid family
 
Date 2011-07-29T07:26:48Z
2011-07-29T07:26:48Z
2011
 
Type Journal Article
 
Identifier Natural Product Reports, vol.28(7); 2011; 1229-1260
http://drs.nio.org/drs/handle/2264/3889
 
Language en
 
Rights An edited version of this paper was published by and © The Royal Society of Chemistry 2011. http://dx.doi.org/10.1039/C0NP00013B
 
Publisher The Royal Society of Chemistry