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Bio-Prospecting of a Few Brown Seaweeds for Their Cytotoxic and Antioxidant Activities

DRS at CSIR-National Institute of Oceanography

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Title Bio-Prospecting of a Few Brown Seaweeds for Their Cytotoxic and Antioxidant Activities
 
Creator Vinayak, R.C.
Sabu, A.S.
Chatterji, A.
 
Subject seaweeds
drugs
Dictyopteris australis
Spatoglossum variabile
Stoechospermum marginatum
Spatoglossum aspermum
 
Description Methanolic extracts (MEs) of seven brown seaweeds occurring in the Indian coastal waters were screened for their cytotoxic and antioxidant properties following various assays. The methanolic extracts of seaweeds in the order of Dictyopteris australis > Spatoglossum variabile > Stoechospermum marginatum > Spatoglossum aspermum showed significant cytotoxic activity. A very high DPPH radical scavenging activity was exhibited by the methanolic extracts prepared from St. marginatum, Padina tetrastromatica, Dictyopteris delicatula and S. aspermum. The total phenolic content of the MEs varied from 13.19 + or - 0.32 to 25.29 + or - 0.445 gallic acid equivalents (mg g sup(?1) of methanolic extract). The reducing power assay indicated a dose dependency, at concentrations of 0.1, 0.5 and 1.0 and 2.0 mg mL sup(-1) of MEs and decreased in the following order: Butylated hydroxy toluene > P. tetrastromatica > D. delicatula > S. aspermum > S. variabile > S. marginatum > D. australis > S. marginatum. Furthermore, D. australis, S. aspermum, S. variabile and S. marginatum demonstrated good metal ion chelating properties. This suggests that the antioxidant compounds found in brown seaweeds scavenge free radicals through effective intervention. This decisively promotes them as a potential source of natural antioxidants.
 
Date 2011-09-19T10:22:01Z
2011-09-19T10:22:01Z
2011
 
Type Journal Article
 
Identifier Evidence-Based Complementary and Alternative Medicine, vol.2011; 2011; doi:10.1093/ecam/neq024
http://drs.nio.org/drs/handle/2264/3907
 
Language en
 
Rights Copyright ? 2011 Rashmi C. Vinayak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 
Publisher Hindawi Publishing