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Chemistry of the nudibranch Aldisa andersoni: Structure and biological activity of phorbazole metabolites

DRS at CSIR-National Institute of Oceanography

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Title Chemistry of the nudibranch Aldisa andersoni: Structure and biological activity of phorbazole metabolites
 
Creator Nuzzo, G.
Ciavatta, M.L.
Kiss, R.
Mathieu, V.
Leclercqz, H.
Manzo, E.
Villani, G.
Mollo, E.
Lefranc, F.
DeSouza, L.
Gavagnin, M.
Guido Cimino, G.
 
Subject growth regulators
inhibitors
feeding behaviour
Aldisa andersoni
 
Description A chemical study of the Indo-Pacific dorid nudibranch Aldisa andersoni resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and N1-methyl-phorbazole A, co-occurring with known phorbazoles A, B and D, have been characterized. Phorbazoles were found to be present mainly in the external part of the mollusc. The structures of the new compounds were determined by interpretation of spectroscopic data, mainly NMR and mass spectrometry and by comparison with the literature data. Evaluation of feeding-deterrence activity as well as in vitro growth inhibitory properties in human cancer cells was also carried out.
 
Date 2012-09-03T09:05:39Z
2012-09-03T09:05:39Z
2012
 
Type Journal Article
 
Identifier Marine Drugs, vol.10; 2012; 1799-1811
http://drs.nio.org/drs/handle/2264/4143
 
Language en
 
Rights OPEN ACCESS
 
Publisher MDPI Publishing