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Synthesis of (R)-norbgugaine and its potential as quorum sensing inhibitor against Pseudomonas aeruginosa

DRS at CSIR-National Institute of Oceanography

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Title Synthesis of (R)-norbgugaine and its potential as quorum sensing inhibitor against Pseudomonas aeruginosa
 
Creator Majik, M.S.
Naik, D.
Bhat, C.
Tilve, S.
Tilvi, S.
DeSouza, L.
 
Subject inhibitors
antibiotics
fungicides
antifouling substances
 
Description (R)-Bgugaine is a natural pyrrolidine alkaloid from Arisarum vulgare, which shows antifungal and antibacterial activity. We have accomplished the simple synthesis of norbgugaine (demethylated form of natural bgugaine) employing Wittig olefination and cat hydrogenation as the key steps and its biological studies are reported for the first time. The synthesized norbgugaine was evaluated for inhibition of quorum sensing mediated virulence factors (motility, biofilm formation, pyocyanin pigmentation, rhamnolipid production and LasA protease) in Pseudomonas aeruginosa wherein swarming motility is reduced by 95 percent, and biofilm formation by 83 percent.
 
Date 2013-04-02T10:03:15Z
2013-04-02T10:03:15Z
2013
 
Type Journal Article
 
Identifier Bioorganic & Medicinal Chemistry Letters, vol.23; 2013; 2353-2356
no
http://drs.nio.org/drs/handle/2264/4277
 
Language en
 
Relation Bioorg_Med_Chem_Lett_23_2353.jpg
 
Rights An edited version of this paper was published by Elsevier. Copyright [2013] Elsevier
 
Publisher Elsevier