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In vitro and in vivo activities of antibiotic PM181104

DRS at CSIR-National Institute of Oceanography

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Title In vitro and in vivo activities of antibiotic PM181104
 
Creator Mahajan, G.B.
Thomas, B.
Parab, R.
Patel, Z.E.
Kuldharan, S.
Yemparala, V.
Mishra, P.D.
Ranadive, P.
DeSouza, L.
Pari, K.
Sivaramkrishnan, H.
 
Subject antibiotics
bacteria
bioactive compounds
sponges
 
Description Drug resistance has become a global threat that, if not addressed, may return us to the preantibiotic era. A way to overcome the problem of growing incidence of global antibiotic resistance is to introduce compounds belonging to classes that are new to the clinic. During a screening of the marine microbial extract library for new antibiotics, one of the extracts showed promising antibacterial activity against Gram-positive organisms. Bioactivity-guided isolation and characterization of active metabolites led to the discovery of a novel thiazolyl cyclic-peptide antibiotic, PM181104. It was isolated and characterized from a marine sponge-associated actinobacterium strain of the genus Kocuria (MTCC 5269). The compound exhibited a potent in vitro antibacterial activity against a broad range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The MIC values evaluated for the compound were found to be in the single-digit nanomolar range. In in vivo studies of PM181104 in a BALB/c murine septicemia model, the compound displayed 100% effective dose (ED100) values of 2.5 and 5.0 mg/kg of body weight against MRSA and 10.0 mg/kg against VRE. In this report, in vitro and in vivo studies of PM181104 are described
 
Date 2013-12-10T05:55:35Z
2013-12-10T05:55:35Z
2013
 
Type Journal Article
 
Identifier Antimicrobial Agents and Chemotherapy, vol.57(11); 2013; 5315-5319
http://drs.nio.org/drs/handle/2264/4401
 
Language en
 
Rights opyright ? American Society for Microbiology
 
Publisher American Society for Microbiology