Record Details

Iodine catalyzed one-pot synthesis of chloro-substituted linear and angular indoloquinolines and in vitro antiproliferative activity study of different indoloquinolines

DRS at CSIR-National Institute of Oceanography

View Archive Info
 
 
Field Value
 
Title Iodine catalyzed one-pot synthesis of chloro-substituted linear and angular indoloquinolines and in vitro antiproliferative activity study of different indoloquinolines
 
Creator Parvatkar, P.T.
Ajay, A.K.
Bhat, M.K.
Parameswaran, P.S.
Tilve, S.G.
 
Subject Alkaloid
Antiproliferative activity
Indoloquinoline
 
Description This article describes a facile one-pot synthesis of different chloro-substituted linear and angular indoloquinolines using iodine as a catalyst and in vitro antiproliferative activity of these chloro-substituted indoloquinolines (3e and 3f) and some indolo[2,3-b]quinolines (3a–d) against human hepatocellular carcinoma HepG2 and human breast carcinoma MCF-7 cells. Anti-proliferative assay against human hepatocellular carcinoma HepG2 and human breast carcinoma MCF-7 cells indicated methyl-substituted 6H-indolo[2,3-b]quinoline 3c to be the most active and the parent 6H-indolo[2,3-b]quinoline 3a to be the least active, while the other compounds including the different chloro derivatives exhibited only intermediate activity.
 
Date 2014-01-13T08:46:56Z
2014-01-13T08:46:56Z
2013
 
Type Journal Article
 
Identifier Medicinal Chemistry Research, vol.22(1); 2013; 88–93
http://drs.nio.org/drs/handle/2264/4423
 
Language en
 
Rights An edited version of this paper was published by Springer. This paper is for R & D purpose and Copyright [2013] Springer.
 
Publisher Springer