Determination of Acetylcholinesterase activities in marine gastropod (Morula granulata) as a biomarker of neurotoxic contaminants along the Goan coast.
DRS at CSIR-National Institute of Oceanography
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Title |
Determination of Acetylcholinesterase activities in marine gastropod (Morula granulata) as a biomarker of neurotoxic contaminants along the Goan coast.
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Creator |
Sarkar, A.
Tegur, P.M. Jana, S. Rao, P.V.S.S.D.P. |
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Subject |
Enzyme
Biomarker Pollution Biomonitoring |
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Description |
Acetylcholinesterase (AChE) is an enzyme that degrades the neurotransmitter acetylcholine, producing choline and acetate. group. It is mainly found at neuromuscular junctions and cholinergic synapses in the central nervous system, where its activity serves to terminate synaptic transmission. The presence of neurotoxic compounds result in measurable inhibition of this enzyme. As a result, acetylcholine is accumulated, there by nervous transmission is interrupted. Therefore, it leads to several diseases or even death. Hence it is considered as a suitable biomarker for detecting environmental pollution caused by the neurotoxic compounds. We have carried out experiments with marine gastropods (Morula granulate) at the selected sites, Arambol, Sinquerim ,Velsao along the Goan coast. The variation of AChE activities along the Goa coast was assessed in comparison with the value of AChE at Betul which was considered as reference site with AChE activity (143.44 nmol/mg/min). The results showed that the highest AChE activity was observed at Sinquerim site (97.85 nmol/mg/min) and the lowest activity at Arambol site (63.66 nmol/mg/min) and the average AChE activity was found at Velsao site (73.22 nmol/mg/min). Thus on the basis of the variation of AChE activities in marine gastropods the contamination of the coastal environment can be evaluated for biomonitoring of pollution by neurotoxic compounds.
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Date |
2014-04-01T04:20:17Z
2014-04-01T04:20:17Z 2011 |
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Type |
Journal Article
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Identifier |
Proceedings of the 3rd International Conference on Ecotoxicology and Environmental Sciences from November 28-30, 2011.; 2011; 229-233.
http://drs.nio.org/drs/handle/2264/4485 |
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Language |
en
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Rights |
Copyright [2011]. All efforts have been made to respect the copyright to the best of our knowledge. Inadvertent omissions, if brought to our notice, stand for correction and withdrawal of document from this repository.
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Publisher |
Institute of Ecotoxicology and Environmental Sciences
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