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Design and synthesis of marine natural product-based 1H-indole-2,3-dione scaffold as a new antifouling/antibacterial agent against fouling bacteria.

DRS at CSIR-National Institute of Oceanography

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Title Design and synthesis of marine natural product-based 1H-indole-2,3-dione scaffold as a new antifouling/antibacterial agent against fouling bacteria.
 
Creator Majik, M.S.
Rodrigues, C.
Mascarenhas, S.
DeSouza, L.
 
Subject Marine natural product
Marine organisms
Marine ecosystem
 
Description Marine organisms such as seaweeds, sponges and corals protect their own surfaces from fouling by their high anesthetic, repellant, and settlement inhibition properties. Within the marine ecosystem, evolution has allowed for the development of certain antifouling properties. Isatin is a biologically active chemical produced by an Alteromonas sp. strain inhibiting the surface of embryos of the cardiean shrimp Palaemon macrodectylus, which protect them from the pathogenic fungus Lagenidium callinectes. In present study, an antibacterial activity of isatin and its synthetic analogues were evaluated against different fouling bacteria in order to explore the structure activity relationships for the first time. The synthesized compounds along with parent isatin were tested against different ecologically relevant marine microorganisms by using the Kirby–Bauer disc diffusion method. Few synthetically modified isatin exhibited potent inhibitory activity at concentration of 2 μg/disc against Planococcus donghaensis, Erythrobacter litoralis, Alivibrio salmonicida, Vibrio furnisii. Overall, the modified analogues showed stronger activity than the parent marine natural product (isatin) and hence 1H-indole-2,3-dione scaffold has immense potential as future antibacterial/antifouling candidate.
 
Date 2014-07-22T10:33:49Z
2014-07-22T10:33:49Z
2014
 
Type Journal Article
 
Identifier Bioorganic Chemistry, vol.54; 2014; 89-95.
no
http://drs.nio.org/drs/handle/2264/4552
 
Language en
 
Relation Bioorg_Chem_54_89.jpg
 
Rights An edited version of this paper was published by Elsevier. Copyright [2014] Elsevier
 
Publisher Elsevier