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Evaluation of single and joint effect of metabolites isolated from marine sponges, Fasciospongia cavernosa and Axinella donnani on antimicrobial properties.

DRS at CSIR-National Institute of Oceanography

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Title Evaluation of single and joint effect of metabolites isolated from marine sponges, Fasciospongia cavernosa and Axinella donnani on antimicrobial properties.
 
Creator Majik, M.S.
Shirodkar, D.
Rodrigues, C.
DeSouza, L.
Tilvi, S.
 
Subject Marine sponges
Macrobiofouling
Antimicrobial
 
Description The biochemical mechanisms that marine sponges have developed as a chemical defense to protect themselves against micro and subsequent macrobiofouling process might comprise a potential alternative for the preventing attack of biofilm forming bacteria. The present study investigated the antimicrobial activity of a series of major secondary metabolites isolated from the sponges Fasciospongia cavernosa and Axinella donnani against fouling bacteria. Secomanoalide (1), dehydromanoalide (2) and cavernosine (3) have been isolated from F. cavernosa. Their structures were determined by MS, 1H NMR spectra analyses and by comparison with those reported in the literature. The most promising activity was exhibited by the metabolites from A. donnani, that is, cerebroside (5) against three strains Aeromonas hydrophila subsp. salmonicida A449 and Erythrobacter litoralis. Our investigation revealed that combined metabolites 1, 2 and 3 retained strong activity but individual metabolite had moderate activity indicating that activity probably results from synergistic interactions between multiple compounds. The antibacterial screening of compounds 3, 5 and synergistic effect of 1–3 against fouling bacteria has been studied for the first time. Further, isolation of manoalide related compounds and their synergistic screening can be accelerated for the development of new biofilm inhibitors.
 
Date 2014-07-22T10:33:59Z
2014-07-22T10:33:59Z
2014
 
Type Journal Article
 
Identifier Bioorganic & Medicinal Chemistry Letters, vol.24(13); 2014; 2863-2866.
no
http://drs.nio.org/drs/handle/2264/4553
 
Language en
 
Relation Bioorg_Med_Chem_Lett_24_2863.jpg
 
Rights An edited version of this paper was published by Elsevier. Copyright [2014] Elsevier
 
Publisher Elsevier