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Construction and screening of 2-aryl benzimidazole library identifies a new antifouling and antifungal agent.

DRS at CSIR-National Institute of Oceanography

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Title Construction and screening of 2-aryl benzimidazole library identifies a new antifouling and antifungal agent.
 
Creator Majik, M.S.
Tilvi, S.
Mascarenhas, S.
Kumar, Vikash.
Chatterjee, Amrita
Banerjee, Mainak.
 
Subject biofouling
antifouling
bacteria
 
Description Biofouling is the undesirable growth of organisms on artificial and natural structures immersed in either seawater or freshwater. It causes huge economic loss and also the global prohibition on known antifouling agents has led to an increased search for safe and effective antifouling agents. In the past, marine natural products have shown tremendous potential by providing new skeletons that could be used as eco-friendly antifouling agents. The library of the 2-aryl benzimidazole core inspired from marine natural products (oroidin and bromoageliferin) was identified and synthesized to explore the antifouling/antifungal properties for the first time. Twelve 2-aryl benzimidazole derivatives were synthesized and evaluated for their antifouling performance against 10 strains of marine biofilm forming bacteria developed on copper panels exposed for 14 days at Dona Paula, Arabian Sea, India. These compounds were also evaluated for their antibacterial and antifungal activities. Two compounds, i.e. 4j and 4l, showed a broad spectrum of antifouling activities against nine marine fouling species, whereas 2-(furan-2-yl)-1H-benzo[d]imidazole 4g showed strong antifungal activity against the clinical pathogen Aspergillus niger. Our results reveal that the 2-aryl substituent on the benzimidazole core had strong impact on their biological profile. Moreover, here we report the first study of the benzimidazole library as a target in 10 representative fouling strains.
 
Date 2014-07-22T10:34:44Z
2014-07-22T10:34:44Z
2014
 
Type Journal Article
 
Identifier RSC Advances, vol.4; 2014; 28259-28264.
http://drs.nio.org/drs/handle/2264/4558
 
Language en
 
Rights An edited version of this paper was published by and © The Royal Society of Chemistry 2014. http://dx.doi.org/10.1039/c4ra00860j
 
Publisher RSC