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Kahalalide F analogues from the mucous secretion of Indian sacoglossan mollusc Elysia ornata

DRS at CSIR-National Institute of Oceanography

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Title Kahalalide F analogues from the mucous secretion of Indian sacoglossan mollusc Elysia ornata
 
Creator Ciavatta, M.L.
PrabhaDevi
Carbone, M.
Mathieu, V.
Kiss, R.
Casapullo, A.
Gavagnin, M.
 
Subject MOLLUSCS
AQUATIC RESOURCES
 
Description Bioassay-guided fractionation of the CHCl3/MeOH extract of Elysia ornata mucus showing antifungal activity led us to isolate kahalalide F(KF) along with two unprecedented related peptides. The structures of kahalalide Z2(1) and kahalalide Z2(2), were established by combination of NMR spectroscopic and mass spectrometry data, also including Marfey amino acid analysis. Compounds 1 and 2 displayed significant antimicrobial properties against several fungal pathogens infesting economically important plants, food, and fish, and were also found to inhibit the in vitro growth of a series of cancer cell lines in a comparable fashion with KF
 
Date 2016-02-04T04:47:09Z
2016-02-04T04:47:09Z
2016
 
Type Journal Article
 
Identifier Tetrahedron, vol.72; 2016; 625-631
http://drs.nio.org/drs/handle/2264/4902
 
Language en
 
Rights An edited version of this paper was published by Elsevier. Copyright [2015] Elsevier
 
Publisher Elsevier