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DNA damage and oxidative stress in marine gastropod Morula granulata exposed to phenanthrene

DRS at CSIR-National Institute of Oceanography

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Title DNA damage and oxidative stress in marine gastropod Morula granulata exposed to phenanthrene
 
Creator Bhagat, J.
Sarkar, A.
Ingole, B.S.
 
Subject MOLLUSCS::Physiology, biochemistry, biophysics
MOLLUSCS::Genetics and evolution
AQUATIC POLLUTION::Effects on organisms
AQUATIC ECOLOGY, PRODUCTIVITY::Environmental effects
 
Description DNA damage and oxidative stress in marine gastropod Morula granulata was measured after in vivo exposure to four different concentrations (10, 25, 50, and 100 mikrog/L) of phenanthrene. Comet assay was used for measurement of DNA damage, whereas oxidative stress was assessed using a battery of biomarkers such as glutathione-S-transferase (GST), catalase (CAT), and lipid peroxidation (LPO). Our data showed concentration-dependent increase in percentage DNA in tail (TDNA), LPO, and GST activity in gastropods exposed to phenanthrene. CAT activity in gastropods was not found to be consistent with the phenanthrene concentrations. Significant increase in TDNA was observed at all concentrations above 10 mikrog/L of phenanthrene. Positive correlations were observed among oxidative stress biomarker and TDNA. Integrated biomarker response (IBR) analysis showed that among the four biomarkers, LPO and DNA damage (TDNA) were the most sensitive in response to phenanthrene exposure. Our results clearly showed that phenanthrene is genotoxic to gastropods and also causes oxidative stress
 
Date 2016-04-11T08:21:51Z
2016-04-11T08:21:51Z
2016
 
Type Journal Article
 
Identifier Water, Air, & Soil Pollution, vol.227(4); 2016; no.114 doi.: 10.1007/s11270-016-2815-1
http://drs.nio.org/drs/handle/2264/4952
 
Language en
 
Rights An edited version of this paper was published by Springer. This paper is for R & D purpose and Copyright [2016] Springer.
 
Publisher Springer