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Synthesis of oxazole, oxazoline and isoxazoline derived marine natural products: A review

DRS at CSIR-National Institute of Oceanography

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Title Synthesis of oxazole, oxazoline and isoxazoline derived marine natural products: A review
 
Creator Tilvi, S.
Singh, K.S.
 
Subject AQUATIC RESOURCES
AQUATIC ECOLOGY, PRODUCTIVITY
MICROBIOLOGY
 
Description Secondary metabolites containing oxazole, oxazoline and isoxazoline ring skeletons are widely distributed in both marine and terrestrial organisms. They possess significant biological activities such as anti-tumor, antibacterial, anti-viral, anti-malarial and immunosuppressive. The complexity in the molecular structures coupled with their wide biological properties, has attracted the attention of many synthetic and natural product chemists. The introduction of multifunctional substituents and the construction of stereo-centers were considered as major challenges and obstacles in developing synthetic protocol for these classes of compounds. Few review articles on the total synthesis of oxazole contaning marine natural products namely bengazoles, phorboxazole, pseudopteroxazoles, hennoxazole and cyclopeptide have been reported till date. However, these reviews omitted the discussion on isolation and biological activities. In this review, we present the brief account on isolation, relevant biological activities and a recent development on the total synthesis of marine natural products containing oxazole, oxazoline and isoxazoline ring skeletons reported till 2014
 
Date 2016-05-12T11:55:36Z
2016-05-12T11:55:36Z
2016
 
Type Journal Article
 
Identifier Current Organic Chemistry, vol.20(8); 2016; 898-929
http://drs.nio.org/drs/handle/2264/4961
 
Language en
 
Rights Copyright [2016]. All efforts have been made to respect the copyright to the best of our knowledge. Inadvertent omissions, if brought to our notice, stand for correction and withdrawal of document from this repository.
 
Publisher Bentham Science Publishers